Protective Effect of Infliximab Against Carbon Tetrachloride-Induced Hepatotoxicity.
RatChemical/toxinSprague-DawleyMalen = 24 rats in three groups of 87 mg/kg24 h before carbon tetrachloride administration
Model: Acute liver injury induced by a single 2 mL/kg dose of carbon tetrachloride
Carbon tetrachloride raised aminotransferases, transforming growth factor beta 1, interleukin 1 beta and adenosine deaminase and lowered carbamoyl phosphate synthetase I and carbonic anhydrase II. Pretreatment with infliximab reversed these changes and reduced histological liver injury.
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