Prevention of interleukin 2-induced acute lung injury in guinea pigs by pentoxifylline.
Guinea pigChemical/toxinIntravenous20 mg/kg intravenous bolus followed by continuous infusion…Bolus started 60 min before interleukin 2 injection
Model: Recombinant human interleukin 2-induced acute lung injury (4 x 10^6 U/kg i.v.)
Pentoxifylline pretreatment prevented the interleukin 2-induced rise in lung water and 125I-albumin lung-to-plasma ratio and prevented accumulation of neutrophils, lymphocytes and macrophages in bronchoalveolar lavage fluid.
Extraction: extract · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.