Protective effect of 1,25-dihydroxyvitamin D3 on ethanol-induced intestinal barrier injury both in vitro and in vivo.
MouseChemical/toxinC57BL/6FemaleDietary (vitamin D-sufficient diet) in vivo; pre-treatment of monolayers in vitroPre-treatment before ethanol exposure
Model: Acute ethanol-induced intestinal barrier injury in mice, with parallel ethanol exposure of Caco-2 cell monolayers
Pre-treatment with 1,25(OH)2D3 ameliorated ethanol-induced barrier dysfunction, tight junction disruption, myosin light chain phosphorylation and reactive oxygen species generation. Mice on a vitamin D-sufficient diet had higher plasma 25(OH)D3 and were more resistant to acute ethanol-induced intes…
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