Exogenous Tryptophan Promotes Cutaneous Wound Healing of Chronically Stressed Mice through Inhibition of TNF-alpha and IDO Activation.
MouseWoundMalen = 20 animals per group across four groupsIntraperitoneal50 mg/kgStarted 1 day after the beginning of the stress protocol, that is 1 day before…
Model: Two 8 mm full-thickness dorsal excisional wounds created 2 days after the start of a chronic restraint stress protocol
Tryptophan reversed the stress-induced fall in plasma tryptophan and rise in normetanephrine, and at day 5 inhibited the stress-induced increases in TNF-alpha, indoleamine 2,3-dioxygenase, lipid peroxidation and inflammatory cell numbers. It restored myofibroblast density, collagen deposition, re-e…
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