Placebo Controlled Trial Of L-Tryptophan In Post-Operative Delirium
Post-operative Delirium
Enrolment: 301 · Results not recorded
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Nutraceutical · L-tryptophan (essential amino acid; serotonin precursor); no curated ChEMBL mechanism record
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Post-operative Delirium
Enrolment: 301 · Results not recorded
Healthy
Enrolment: 7 · Results not recorded
1 studies reported at therapy level; 1 evidence entries itemised.
Model: Two 8 mm full-thickness dorsal excisional wounds created 2 days after the start of a chronic restraint stress protocol
Tryptophan reversed the stress-induced fall in plasma tryptophan and rise in normetanephrine, and at day 5 inhibited the stress-induced increases in TNF-alpha, indoleamine 2,3-dioxygenase, lipid peroxidation and inflammatory cell numbers. It restored myofibroblast density, collagen deposition, re-e…
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.