Effects of hydrogen-rich saline on early acute kidney injury in severely burned rats by suppressing oxidative stress induced apoptosis and inflammation.
RatBurnScaldSprague-DawleyMalen = 56 rats in total, 8 per groupIntraperitoneal10 ml/kgImmediately after the burn
Model: Full-thickness scald burn of 40% total body surface area produced by immersing the shaved back in 100 degrees C water for 15 s under sodium pentobarbital anaesthesia (50 mg/kg intraperitoneally), with early acute kidney injury assessed at 6, 24 and 72 h
Hydrogen-rich saline improved renal function and reduced tubular apoptosis, markedly lowered oxidation-reduction potential and malondialdehyde, raised endogenous antioxidant enzyme activities, decreased myeloperoxidase and inflammatory mediator release, inhibited p38, JNK, ERK and NF-kappaB activat…
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