Dextromethorphan provides neuroprotection via anti-inflammatory and anti-excitotoxicity effects in the cortex following traumatic brain injury.
RatTBIControlled cortical impactSprague-DawleyMaleIntraperitoneal30 mg/kg body weightImmediately after injury
Model: Controlled cortical impact traumatic brain injury
Dextromethorphan significantly reduced brain oedema and neurological deficits and increased neuronal survival, with lower pro-inflammatory cytokines and higher glutamate transporter expression in cortex.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.