AXS-05 (dextromethorphan-bupropion) in subjects with major depressive disorder
Major Depressive Disorder
Enrolment: 327 · Results not recorded
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Drug · Sigma opioid receptor agonist (AGONIST); glutamate [NMDA] receptor subunit epsilon 1 (GluN2A) antagonist (ANTAGONIST)
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Major Depressive Disorder
Enrolment: 327 · Results not recorded
Schizophrenia
Enrolment: 161 · Results not recorded
Neuropathic Pain
Enrolment: 7 · Results not recorded
Idiopathic Pulmonary Fibrosis
Enrolment: 60 · Results not recorded
Common Cold
Enrolment: 28 · Results not recorded
Healthy Subjects · HIV Infection
Enrolment: 24 · Results not recorded
Advanced Solid Tumors · Metastatic Melanoma
Enrolment: 56 · Results not recorded
Healthy Volunteers
Enrolment: 14 · Results not recorded
AOD Effects and Consequences
Enrolment: 16 · Results not recorded
Rett Syndrome
Enrolment: 120 · Results not recorded
2 studies reported at therapy level; 2 evidence entries itemised.
Model: Controlled cortical impact traumatic brain injury
Dextromethorphan significantly reduced brain oedema and neurological deficits and increased neuronal survival, with lower pro-inflammatory cytokines and higher glutamate transporter expression in cortex.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.
Model: Heatstroke induced by exposing anaesthetised rats to 43 degrees Celsius for 68 min
Dextromethorphan at 30 mg/kg extended survival time to 193 to 209 min against 25 to 31 min in vehicle-treated heatstroke rats and exceeded MK-801 at 121 to 133 min, and reduced lung oedema, neutrophil infiltration, haemorrhage, pleurisy and lavage inflammatory and oxidative markers, whereas SA4503…
Extraction: extract · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.