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PRECLINICAL PUBLICATION · 2015

Fresh frozen plasma and spray-dried plasma mitigate pulmonary vascular permeability and inflammation in hemorrhagic shock.

Mouse / Haemorrhage/shock

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

PMID 26002267 ↗2015Reported benefit

Fresh frozen plasma and spray-dried plasma mitigate pulmonary vascular permeability and inflammation in hemorrhagic shock.

MouseHaemorrhage/shockControlledC57BL/6MaleResuscitation after haemorrhagic shock

Model: Haemorrhagic shock and trauma

FFP and SDP performed similarly, preserving endothelial monolayer integrity in vitro, reducing pulmonary vascular permeability, correcting mean arterial pressure and base excess, and reducing alveolar wall thickening, leukocyte infiltration and endothelial junction breakdown, whereas lactated Ringe…

Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.55. Machine-extracted fields require source verification.