Attenuation of radiation-induced gastrointestinal damage by epidermal growth factor and bone marrow transplantation in mice.
MouseRadiationC57Black/6FemaleEGF route not stated; BMT by cell transplantationEGF 2 mg/kg; BMT 5 x 10^6 bone marrow cells from GFP syngen…EGF first dose 24 h after irradiation; BMT 4 h after irradiation. In the surviv…
Model: High-dose whole-body irradiation (12 and 13 Gy, 60Co, 0.59-0.57 Gy/min) causing gastrointestinal damage
BMT and EGF each increased survival after 13 Gy and attenuated radiation-induced gastrointestinal atrophy while increasing regeneration in the first week, with the combination most effective; neither improved early cytopenia.
Extraction: extract · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.