The role of PPAR activation during the systemic response to brain injury.
RatIschaemia-reperfusionCerebral (MCAO/stroke)WistarMalen = 84 rats total (42 control diet, 42 fenofibrate diet); n = 7…Oral, in diet0.2% fenofibrate in diet, stated by the authors as roughly…Pre-treatment for 14 days before induction of ischaemia
Model: 60 min intraluminal thread middle cerebral artery occlusion followed by reperfusion, assessed at 6 h and 24 h
A 14-day fenofibrate diet reduced hepatic acute phase reactant expression (CXCL10 and SAA-1), reduced infarct volume from about 50 to 28 mm3, and cut liver neutrophil numbers by 78% at 24 h after MCAO.
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