Fenofibrate on Adipocytokine Levels in Hypertriglyceridemia
Hypertriglyceridemia
Enrolment not recorded · Results not recorded
Loading the evidence…
Drug · EXACT ENTITY MATCH. CHEMBL672 fenofibrate, approved 1993, ATC C10AB05, oral, prodrug flag=1, not withdrawn, no black box. get_mechanism mec_id 433: PPAR-alpha AGONIST, target CHEMBL239, direct_interaction=true, disease_efficacy=true. Active metabolite fenofibric acid = CHEMBL981 (approved 2008) and choline fenofibrate = CHEMBL1201745 (ABT-335 / Trilipix, ATC C10AB11) are the same molecular family and are noted here rather than as separate records. 10 trials recorded from the first page of intervention search 'fenofibrate'; the API returned a next_page_token so this is a CAPPED sample of a much larger trial set, not an exhaustive count. Most are lipid indications; NCT07025005 (prophylaxis of bortezomib-induced peripheral neuropathy, RECRUITING) is the closest tissue-injury indication.
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Hypertriglyceridemia
Enrolment not recorded · Results not recorded
Diabetic Retinopathy
Enrolment: 80 · Results not recorded
Peripheral Neuropathy · Multiple Myeloma
Enrolment: 44 · Results not recorded
Klinefelter Syndrome
Enrolment: 44 · Results not recorded
Mixed Dyslipidemias
Enrolment: 362 · Results not recorded
Dyslipidemias · Coronary Heart Disease · Mixed Dyslipidemia
Enrolment: 543 · Results not recorded
COVID-19 · Respiratory Distress Syndrome · SARS-CoV-2 Infection
Enrolment: 55 · Results not recorded
Inflammatory Bowel Diseases
Enrolment: 60 · Results not recorded
1 studies reported at therapy level; 1 evidence entries itemised.
Model: 60 min intraluminal thread middle cerebral artery occlusion followed by reperfusion, assessed at 6 h and 24 h
A 14-day fenofibrate diet reduced hepatic acute phase reactant expression (CXCL10 and SAA-1), reduced infarct volume from about 50 to 28 mm3, and cut liver neutrophil numbers by 78% at 24 h after MCAO.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.