SIRT1 protects rat lung tissue against severe burn-induced remote ALI by attenuating the apoptosis of PMVECs via p38 MAPK signaling.
RatBurnScaldSprague-DawleyMalen = 96 rats total: 66 for tissue sampling (sham n = 6, burn n =…Intraperitoneal50 mg/kg body weight in vivo; 20 micromolar in vitroImmediately after burn injury
Model: Full-thickness scald burn over 30% total body surface area (92 degrees C water, 18 s) with remote acute lung injury
Resveratrol upregulated SIRT1 and reduced burn-induced lung histopathology score, pro-inflammatory cytokine expression, cleaved caspase-3 and BALF protein leak; SIRT1 knockdown had the opposite effect, implicating p38 MAPK signalling.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.