Stimulation of Dopamine D3 Receptor Attenuates Renal Ischemia-Reperfusion Injury via Increased Linkage With Galpha12.
RatIschaemia-reperfusionRenalWistarMaleIntravenous0.2 mg/kg15 minutes before clamping, or before hypoxia in vitro
Model: Renal unilateral clamping ischaemia-reperfusion model; in vitro hypoxia/reoxygenation and cold storage/rewarming in NRK52E cells
PD128907 pre-treatment protected against renal ischaemia-reperfusion injury and increased 7-day survival, raising glutathione and superoxide dismutase, lowering malondialdehyde, cytokines, myeloperoxidase and apoptosis, in parallel with increased D3R-Galpha12 linkage.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.