THERAPY DOSSIER · th-6d8bb2540f08

PD128907

Drug

Evidence & regulatory context

Mechanism: Not recorded
Target: Not recorded
Injury models: Ischaemia-reperfusion
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 25989500 ↗2015Reported benefit

Stimulation of Dopamine D3 Receptor Attenuates Renal Ischemia-Reperfusion Injury via Increased Linkage With Galpha12.

RatIschaemia-reperfusionRenalWistarMaleIntravenous0.2 mg/kg15 minutes before clamping, or before hypoxia in vitro

Model: Renal unilateral clamping ischaemia-reperfusion model; in vitro hypoxia/reoxygenation and cold storage/rewarming in NRK52E cells

PD128907 pre-treatment protected against renal ischaemia-reperfusion injury and increased 7-day survival, raising glutathione and superoxide dismutase, lowering malondialdehyde, cytokines, myeloperoxidase and apoptosis, in parallel with increased D3R-Galpha12 linkage.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.

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