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PRECLINICAL PUBLICATION · 2015

Acute theophylline exposure modulates breathing activity through a cervical contusion.

Rat / Spinal cord injury

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

PMID 25979115 ↗2015Reported benefit

Acute theophylline exposure modulates breathing activity through a cervical contusion.

RatSpinal cord injuryHemisection / partialMale15 mg/kgThree weeks after the C3/4 contusion, given before the contralateral C2 hemisec…

Model: Unilateral C3/4 cervical spinal contusion (150 kdyn) followed three weeks later by contralateral C2 hemisection

Theophylline-treated rats sustained breathing through damaged pathways for up to 2 minutes, whereas saline-treated rats could not support ventilation.

Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.