ADC4022 (Theophylline) on Markers of Pulmonary Inflammation in Moderate-Severe COPD
Chronic Obstructive Pulmonary Disease
Enrolment: 91 · Results not recorded
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Drug · Theophylline (methylxanthine): nonselective adenosine receptor antagonist and phosphodiesterase inhibitor; approved bronchodilator (ChEMBL parent CHEMBL190)
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Chronic Obstructive Pulmonary Disease
Enrolment: 91 · Results not recorded
High Altitude Pulmonary Hypertension
Enrolment: 20 · Results not recorded
Post-Dural Puncture Headache
Enrolment: 75 · Results not recorded
1 studies reported at therapy level; 1 evidence entries itemised.
Model: Unilateral C3/4 cervical spinal contusion (150 kdyn) followed three weeks later by contralateral C2 hemisection
Theophylline-treated rats sustained breathing through damaged pathways for up to 2 minutes, whereas saline-treated rats could not support ventilation.
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.