Mitochondrial Division Inhibitor 1 Ameliorates Mitochondrial Injury, Apoptosis, and Motor Dysfunction After Acute Spinal Cord Injury in Rats.
RatSpinal cord injuryUnspecifiedSprague-DawleyFemale1.2 mg/kg (neuroprotection described as dose-dependent, oth…
Model: Acute spinal cord injury in rats
Mdivi-1 at 1.2 mg/kg suppressed Drp1 and Bax translocation to mitochondria, limited mitochondrial depolarisation and oxidative stress, reduced caspase-dependent and independent apoptosis, and improved motor function from 3 to 10 days after injury.
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