THERAPY DOSSIER · th-6bbbbf00daf1

Mitochondrial division inhibitor 1 (Mdivi-1)

Drug · Mitochondrial division inhibitor 1 (Mdivi-1) is a DRP1 (dynamin-related protein 1) inhibitor (research tool); no confident ChEMBL name match returned

Non-drug Suggest a correction

Evidence & regulatory context

Mechanism: Mitochondrial division inhibitor 1 (Mdivi-1) is a DRP1 (dynamin-related protein 1) inhibitor (research tool); no confident ChEMBL name match returned
Target: Not recorded
Injury models: Spinal cord injury
Reported indication: Not recorded
First approval: Not recorded
Development stage: Not recorded
ChEMBL record: Not recorded
ChEMBL max phase: Not recorded
Synonyms: Not recorded
Note: Not recorded

Clinical trials 0

0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.

No linked human trial in this dataset.

Preclinical evidence 1

1 studies reported at therapy level; 1 evidence entries itemised.

PMID 25968480 ↗2015Reported benefit

Mitochondrial Division Inhibitor 1 Ameliorates Mitochondrial Injury, Apoptosis, and Motor Dysfunction After Acute Spinal Cord Injury in Rats.

RatSpinal cord injuryUnspecifiedSprague-DawleyFemale1.2 mg/kg (neuroprotection described as dose-dependent, oth…

Model: Acute spinal cord injury in rats

Mdivi-1 at 1.2 mg/kg suppressed Drp1 and Bax translocation to mitochondria, limited mitochondrial depolarisation and oxidative stress, reduced caspase-dependent and independent apoptosis, and improved motor function from 3 to 10 days after injury.

Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.

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