Effects of autologous SCF- and G-CSF-mobilized bone marrow stem cells on hypoxia-inducible factor-1 in rats with ischemia-reperfusion renal injury.
RatIschaemia-reperfusionRenalSprague-DawleyMaleSCF 200 micrograms/kg/day and G-CSF 50 micrograms/kg/dayStarted 6 h after induction of renal ischaemia-reperfusion injury
Model: Renal ischaemia-reperfusion injury with acute tubular necrosis in rats
Combined SCF and G-CSF increased bone marrow stem cell numbers in damaged kidney and reduced the degree of renal tissue damage, with higher HIF-1 alpha, VEGF and erythropoietin expression than in other groups.
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