Effects of human epidermal growth factor on natural and delayed healing of acetic acid-induced gastric ulcers in rats.
RatChemical/toxinInbred strain not specifiedMaleSubcutaneous100 and 300 micrograms/kgAfter ulcer induction
Model: Gastric ulcer induced by submucosal injection of 0.03 ml of 20% acetic acid; delayed healing produced by daily indomethacin 1 mg/kg subcutaneously for 4 weeks
hEGF at 100 and 300 micrograms/kg significantly accelerated both natural and indomethacin-delayed healing of acetic acid gastric ulcers, and inhibited basal and histamine-stimulated acid secretion, suggesting healing is mediated largely by antisecretory activity.
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