Neuroprotective effects of MK-801 against traumatic brain injury in immature rats.
RatTBIUnspecifiedWistarIntraperitoneal1 mg/kg body weightImmediately after induction of traumatic injury
Model: Contusion traumatic brain injury in immature rat pups
A single 1 mg/kg intraperitoneal dose reduced trauma-induced hippocampal neuron loss, altered BDNF, NGF and NMDA receptor expression, and improved anxiety-related behaviour and hippocampus-dependent memory two months later.
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