Rapamycin increases neuronal survival, reduces inflammation and astrocyte proliferation after spinal cord injury.

Rapamycin increases neuronal survival, reduces inflammation and astrocyte proliferation after spinal cord injury.

Model: Spinal cord hemisection in mice

A single rapamycin injection reduced inflammatory cell infiltration, microglial activation and TNF-alpha secretion, limited astrocyte proliferation and GFAP expression at the lesion, and increased neuronal survival and axonogenesis towards the lesion.

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