Autophagy protects against ischemia/reperfusion-induced lung injury through alleviating blood-air barrier damage.
MouseIschaemia-reperfusionOther / unspecifiedPre-conditioning before ischaemia/reperfusion challenge; U0126 pre-injected bef…
Model: Lung ischaemia/reperfusion injury in mice, with oxygen-glucose deprivation and restoration in human pulmonary microvascular endothelial cells
Promoting autophagy with rapamycin significantly alleviated ischaemia/reperfusion-induced lung oedema and tissue inflammation and reduced endothelial junction damage and cell death, whereas inhibiting autophagy aggravated injury.
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