Red blood cell washing, nitrite therapy, and antiheme therapies prevent stored red blood cell toxicity after trauma-hemorrhage.
MouseHaemorrhage/shockControlledC57BL/6MaleIntravenousNitrite 10 or 100 micromol intravenous bolus (stock solutio…Nitrite at resuscitation with stored red blood cells; TAK-242 before haemorrhag…
Model: Trauma plus controlled haemorrhage with resuscitation using red blood cells stored 0 to 10 days (1 or 3 units)
Transfusion of 5 day stored red blood cells increased lung injury; nitrite prevented this whereas washing did not. Ten day stored cells caused approximately 90 per cent lethality versus under 15 per cent with 5 day cells, and both washing and nitrite significantly protected against this lethality.…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.