Intracoronary Nitrite Infusion During Acute Myocardial Infarction
Myocardial Infarction · Reperfusion Injury
Enrolment: 80 · Results not recorded
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Drug · Multi-component intervention. Sodium nitrite CHEMBL93268 (parent CHEMBL1161681), approved 2011, ATC V03AB08, black box warning, no curated ChEMBL mechanism. TAK-242 = resatorvid CHEMBL225157, max_phase 3, Toll-like receptor 4 inhibitor (target CHEMBL5255). Hemopexin (human) CHEMBL5315017 = CSL-889, max_phase 1, no curated mechanism. Red blood cell washing is a transfusion-medicine procedure with no ChEMBL entry.
1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Myocardial Infarction · Reperfusion Injury
Enrolment: 80 · Results not recorded
Out-Of-Hospital Cardiac Arrest
Enrolment: 1502 · Results not recorded
Acute ST Elevation Myocardial Infarction
Enrolment: 200 · Results not recorded
Pulmonary Arterial Hypertension
Enrolment: 17 · Results not recorded
Diabetes
Enrolment: 26 · Results not recorded
Coronary Artery Bypass Surgery
Enrolment: 50 · Results not recorded
Heart Failure
Enrolment: 15 · Results not recorded
Out-Of-Hospital Cardiac Arrest
Enrolment: 120 · Results not recorded
Hypertension · Cardiovascular Diseases
Enrolment: 14 · Results not recorded
Healthy
Enrolment: 36 · Results not recorded
Sickle Cell Anemia · Chronic Hemolytic Disorders
Enrolment: 28 · Results not recorded
2 studies reported at therapy level; 2 evidence entries itemised.
Model: Trauma plus controlled haemorrhage with resuscitation using red blood cells stored 0 to 10 days (1 or 3 units)
Transfusion of 5 day stored red blood cells increased lung injury; nitrite prevented this whereas washing did not. Ten day stored cells caused approximately 90 per cent lethality versus under 15 per cent with 5 day cells, and both washing and nitrite significantly protected against this lethality.…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.85. Machine-extracted fields require source verification.
Model: Crush syndrome: bilateral hind limb compression with rubber tourniquets for 5 h followed by up to 6 h reperfusion
Muscle nitrite was reduced during ischaemia-reperfusion in crush syndrome. Nitrite restored muscle nitrite and nitric oxide bioavailability, lowered potassium, lactate dehydrogenase and creatine phosphokinase, reduced plasma interleukin-6 and myeloperoxidase in muscle and lung, and dose-dependently…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.8. Machine-extracted fields require source verification.