Schwann cells generated from neonatal skin-derived precursors or neonatal peripheral nerve improve functional recovery after acute transplantation into the partially injured cervical spinal cord of the rat.
RatSpinal cord injuryCompressionSprague-Dawley (including transgenic GFP donors)Intraspinal transplantation into the injured cervical cordAcute transplantation shortly after injury
Model: Incomplete cervical spinal cord crush injury
Rats receiving Schwann cells from either skin-derived precursors or peripheral nerve showed improved functional recovery at 10 weeks relative to media or fibroblast controls, with enhanced rubrospinal tract sparing or plasticity and greater host tissue preservation, despite limited graft survival.…
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