Safety and Efficacy of Autologous Human Schwann Cell (ahSC) Augmentation in Severe Peripheral Nerve Injury (PNI)
Peripheral Nerve Injury
Enrolment: 30 · Results not recorded
Biologic · Cell therapy with no ChEMBL entity, so ChEMBL was NOT queried; resolved=false by modality. STRONG MODALITY MATCH, one of the better translations in this batch: all 7 recorded trials are autologous human Schwann cell (ahSC) products from the same Miami Project / W. Dalton Dietrich programme, in peripheral nerve injury and spinal cord injury, i.e. exact injury indications. IMPORTANT DIFFERENCE recorded knowingly: the human product is expanded from ADULT AUTOLOGOUS peripheral nerve, NOT from neonatal skin-derived precursors; no human trial uses SKP-derived Schwann cells. 3 of the 7 are EXPANDED ACCESS records with status NO_LONGER_AVAILABLE and no enrolment, so the interventional evidence base is 4 Phase 1 studies totalling roughly 52 planned participants.
7 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Peripheral Nerve Injury
Enrolment: 30 · Results not recorded
Spinal Cord Injury · Paraplegia
Enrolment: 9 · Results not recorded
Peripheral Nerve Injuries
Enrolment: 5 · Results not recorded
Spinal Cord Injury · Paraplegia · Quadriplegia · Tetraplegia
Enrolment: 8 · Results not recorded
Sciatic Nerve Injury
Enrolment not recorded · Results not recorded
Peripheral Nerve Injuries
Enrolment not recorded · Results not recorded
Sciatic Nerve Injury
Enrolment not recorded · Results not recorded
1 studies reported at therapy level; 1 evidence entries itemised.
Model: Incomplete cervical spinal cord crush injury
Rats receiving Schwann cells from either skin-derived precursors or peripheral nerve showed improved functional recovery at 10 weeks relative to media or fibroblast controls, with enhanced rubrospinal tract sparing or plasticity and greater host tissue preservation, despite limited graft survival.…
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.