Anti-edema effect of melatonin on spinal cord injury in rats.
RatSpinal cord injuryCompressionSprague-DawleyMalen = 150 adult male rats, 50 per group across sham, injury and m…Intraperitoneal100 mg/kgImmediately after spinal cord injury
Model: Laminectomy followed by spinal cord compression injury in rats
Melatonin at 100 mg/kg left spinal cord water content essentially unchanged at 12 h but significantly reduced it from 24 to 72 h, and decreased aquaporin-4 and GFAP expression between 24 and 72 h after injury.
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