The monoacylglycerol lipase inhibitor JZL184 decreases inflammatory response in skeletal muscle contusion in rats.
RatCrushLimb / muscle crushSprague-DawleyMale
Model: Skeletal muscle contusion in rats
JZL184 reduced neutrophil and macrophage infiltration and pro-inflammatory cytokine expression, but myofibre regeneration was significantly hindered with increased collagen I and III mRNA, greater fibroblast infiltration and promoted fibrosis; CB1 and CB2 antagonists alleviated the anti-inflammator…
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.