Drug · ChEMBL compound_search 'JZL184' returned 0 hits: an EXPLICIT NEGATIVE RESULT. AM281 and AM630 were NOT queried within the time budget (they are mechanistic tool antagonists, not the candidate therapy), so their absence is an OMISSION for those two agents. CLASS-LEVEL FLAG recorded knowingly: JZL184 is a preclinical monoacylglycerol lipase (MAGL) inhibitor that has never entered human study. All 8 recorded trials are DIFFERENT clinical-stage MAGL inhibitors: ABX-1431 / lu-JZP (Abide Therapeutics, 6 trials), Lu AG06466 (Lundbeck PET occupancy) and RO7268489 (Roche, Phase 2 in progressive MS). Indications are central and peripheral neuropathic pain, Tourette syndrome, functional dyspepsia and MS; NCT03447756 includes post-traumatic neuralgia, the only injury-adjacent indication. NCT02875678 is TERMINATED at n=4.
1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Post Herpetic Neuralgia · Diabetic Peripheral Neuropathy · Small Fiber Neuropathy · Post-Traumatic Neuralgia
Enrolment: 39 · Results not recorded
Progressive Multiple Sclerosis
Enrolment: 360 · Results not recorded
Tourette Syndrome · Motor Tic Disorder
Enrolment: 50 · Results not recorded
Neuromyelitis Optica Spectrum Disorder · Transverse Myelitis · Multiple Sclerosis · Longitudinally Extensive Transverse Myelitis
Enrolment: 9 · Results not recorded
Pain
Enrolment: 16 · Results not recorded
Dyspepsia
Enrolment: 4 · Results not recorded
Healthy
Enrolment: 16 · Results not recorded
Tourette Syndrome · Chronic Motor Tic Disorder
Enrolment: 23 · Results not recorded
1 studies reported at therapy level; 1 evidence entries itemised.
Model: Skeletal muscle contusion in rats
JZL184 reduced neutrophil and macrophage infiltration and pro-inflammatory cytokine expression, but myofibre regeneration was significantly hindered with increased collagen I and III mRNA, greater fibroblast infiltration and promoted fibrosis; CB1 and CB2 antagonists alleviated the anti-inflammator…
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.
