Local Application of Gelatin Hydrogel Sheets Impregnated With Platelet-Derived Growth Factor BB Promotes Tendon-to-Bone Healing After Rotator Cuff Repair in Rats.
RatOtherSprague-DawleyMalen = 36 adult rats undergoing bilateral surgery, allocated to th…Local application of the hydrogel sheet lateral to the repaired tendon0.5 micrograms PDGF-BB per gelatin hydrogel sheetAt the time of surgical repair
Model: Bilateral transection and acute suture repair of the supraspinatus tendon at its insertion (rotator cuff repair)
At 2 weeks PCNA positive cells at the insertion were higher with PDGF-BB (40.5 plus or minus 2.4 per cent) than suture only (32.1 plus or minus 6.9 per cent, P equals 0.03) or PBS hydrogel (31.9 plus or minus 3.7 per cent, P equals 0.02). At 12 weeks the histologic score was higher (10.3 plus or mi…
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