rhPDGF-BB-Enhanced Wound Matrix in Reconstruction of Full-Thickness Head/Neck Defects After Skin Cancer Excision
Wound Healing · Surgical Wound
Enrolment: 36 · Results not recorded
Loading the evidence…
Biologic · Platelet-derived growth factor receptor agonist (AGONIST)
2 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Wound Healing · Surgical Wound
Enrolment: 36 · Results not recorded
Burns
Enrolment: 120 · Results not recorded
Peri-Implantitis
Enrolment: 11 · Results not recorded
Martorell's Ulcer · Hypertensive Leg Ulcer
Enrolment: 64 · Results not recorded
Foot Ulcer · Diabetic Foot · Skin Ulcer
Enrolment: 84 · Results not recorded
Intrabony Periodontal Defect
Enrolment: 60 · Results not recorded
Lateral Epicondylitis
Enrolment: 100 · Results not recorded
Diabetic Foot Ulcers
Enrolment: 40 · Results not recorded
Defect of Articular Cartilage
Enrolment: 1 · Results not recorded
Gingival Recession
Enrolment: 30 · Results not recorded
Healing of Extraction Socket
Enrolment: 0 · Results not recorded
Tooth Extraction · Immediate Implant Placement
Enrolment: 0 · Results not recorded
4 studies reported at therapy level; 4 evidence entries itemised.
Model: Bilateral transection and acute suture repair of the supraspinatus tendon at its insertion (rotator cuff repair)
At 2 weeks PCNA positive cells at the insertion were higher with PDGF-BB (40.5 plus or minus 2.4 per cent) than suture only (32.1 plus or minus 6.9 per cent, P equals 0.03) or PBS hydrogel (31.9 plus or minus 3.7 per cent, P equals 0.02). At 12 weeks the histologic score was higher (10.3 plus or mi…
Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.
Model: Acute detachment and repair of the supraspinatus tendon (rotator cuff repair model)
rhPDGF-BB produced a dose-dependent increase in cellular proliferation and angiogenesis at 5 days but did not improve fibrocartilage formation or collagen maturity at 28 days, and all scaffold-containing groups had lower load to failure and stiffness than repair-only controls.
Extraction: extract · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.
Model: Acute Achilles tendon transection proximal to the calcaneal insertion, immediately repaired with sutures
Ultimate tensile strength increased significantly in the two highest dose groups (1.9 plus or minus 0.5 and 2.1 plus or minus 0.5 MPa) versus control (1.0 plus or minus 0.2 MPa), and modulus increased in the highest dose group (7.2 plus or minus 3.8 versus 3.5 plus or minus 0.9 MPa, p = 0.031). Max…
Extraction: extract · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.
Model: Acute haemorrhagic shock
Systemic PDGF-BB improved haemodynamics, perfusion of liver and kidney, vascular reactivity and survival after haemorrhagic shock. The effect depended on endothelial integrity and myoendothelial gap junctions and was abolished by connexin 43 antisense but not connexin 40 antisense.
Extraction: extract · Supplied extraction confidence: 0.7. Machine-extracted fields require source verification.