Subdural infusion of dexamethasone inhibits leukomyelitis after acute spinal cord injury in a rat model.
RatSpinal cord injuryCompressionLong-EvansMale and femaleSubdural infusionAfter acute spinal cord injury
Model: Epidural balloon crush injury of the cranial thoracic spinal cord
One week of subdural dexamethasone infusion markedly inhibited macrophage infiltration of the crush cavity and prevented phagocytic removal of myelin debris, indicating suppression of the severe inflammatory response directed at damaged myelin. Functional outcomes were not reported.
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.