Tissue responses to postoperative laser therapy in diabetic rats submitted to excisional wounds.
RatWoundWistarFemalen = Three groups of 30 animals each (90 total)Topical laser irradiation of the woundSingle-dose group 4 J/cm2; fractionated-dose group 1 J/cm2…Immediate postoperative period, starting on day 1 after wounding
Model: 8 mm full-thickness excisional dorsal skin wound in streptozotocin-induced diabetic rats (streptozotocin 60 mg/kg intraperitoneally)
Both laser regimens accelerated wound closure by approximately 40% during the first three days compared with untreated controls, increased acute inflammatory infiltrate up to day 3, and produced more myofibroblasts and better organised collagen. Single 4 J/cm2 and four 1 J/cm2 applications gave sim…
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