SIRT1 mediates a primed response to immune challenge after traumatic lung injury.
MouseOtherC57BL/6MaleIntraperitoneal30 mg/kg6 hours after pulmonary contusion, 18 hours before caecal ligation and puncture…
Model: Pulmonary contusion followed by second-hit challenge with caecal ligation and puncture or intratracheal lipopolysaccharide
Pulmonary contusion reduced lung SIRT1 protein, messenger RNA and enzyme activity and primed mice for exaggerated responses to infection or lipopolysaccharide. Resveratrol treatment decreased polymorphonuclear leukocyte influx into bronchoalveolar lavage after intratracheal lipopolysaccharide (50 u…
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