PRECLINICAL PUBLICATION · 2015

Recombinant human brain natriuretic peptide ameliorates trauma-induced acute lung injury via inhibiting JAK/STAT signaling pathway in rats.

Rat / Other

Evidence by therapy association

Study details and outcomes are extracted in the context of a specific intervention. Separate associations are retained rather than silently merged.

Recombinant human brain natriuretic peptide (rhBNP)

PMID 25909419 ↗2015Reported benefit

Recombinant human brain natriuretic peptide ameliorates trauma-induced acute lung injury via inhibiting JAK/STAT signaling pathway in rats.

RatOtherSprague-DawleyMalePretreatment before induction of acute lung injury

Model: Trauma-induced acute lung injury

Pretreatment with rhBNP improved hypoxaemia, reduced pulmonary oedema and histopathological injury, lowered phosphorylated and total STAT1, and inhibited JAK2 and STAT3 phosphorylation, similarly to the JAK inhibitor AG490.

Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.