Evidence & regulatory context
- Mechanism
- Atrial natriuretic peptide receptor A agonist
- Target
- CHEMBL1988
- Injury models
- Other
- Reported indication
- Nesiritide approved for intravenous treatment of acutely decompensated congestive heart failure with dyspnea at rest; FDA-approved 2001 (Natrecor)
- First approval
- 2001
- Development stage
- Approved 2001 for acute decompensated HF but ASCEND-HF neutral; commercially discontinued 2018; renal-protection use unproven
- ChEMBL max phase
- 4 / 4 (development scale, not regulatory approval)
- Synonyms
- Nesiritide; Nesiritide recombinant; BNP-32; Brain natriuretic peptide 32; Natrecor
- Note
- Not recorded
Clinical trials 4
1 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Perioperative Recombinant Human Brain Natriuretic Peptide for Renal Protection in Cardiac Surgery: the PROTECT-CS Randomized Clinical Trial
AKI - Acute Kidney Injury · Cardiac Surgical Procedures · Cardiopulmonary Bypass
Enrolment: 694 · Results not recorded
Mechanism(s) Underlying Hypotensive Response to ARB/NEP Inhibition - Aim 1 (includes BNP infusion arm)
Hypertension
Enrolment: 4 · Results not recorded
Novel Peptides in Resistant Human Hypertension (nesiritide/BNP)
Hypertension
Enrolment: 12 · Results not recorded
Low Dose Continuous Infusion of BNP (Nesiritide) in the Prevention of Renal Insufficiency Post Cardiopulmonary Bypass Cardiac Surgery.
Acute Kidney Failure
Enrolment: 40 · Results not recorded
Preclinical evidence 1
1 studies reported at therapy level; 1 evidence entries itemised.
RatOtherSprague-DawleyMalePretreatment before induction of acute lung injury
Model: Trauma-induced acute lung injury
Pretreatment with rhBNP improved hypoxaemia, reduced pulmonary oedema and histopathological injury, lowered phosphorylated and total STAT1, and inhibited JAK2 and STAT3 phosphorylation, similarly to the JAK inhibitor AG490.
Extraction: extract · Supplied extraction confidence: 0.6. Machine-extracted fields require source verification.
