Metformin attenuates myocardial remodeling and neutrophil recruitment after myocardial infarction in rat.
RatOtherWistarMalen = 6 groups of 6 rats; separate histopathology subgroups of 5…Oral (volume 0.25 to 0.5 mL)25, 50 and 100 mg/kg per 12 hChronic pretreatment started 12 days before infarction induction and continued…
Model: Isoproterenol-induced acute myocardial infarction (isoproterenol 100 mg/kg/day subcutaneously on two consecutive days)
All three metformin doses attenuated isoproterenol-induced cardiomyocyte necrosis and fibrosis and reduced the heart to body weight ratio. Necrosis grade fell dose-dependently from 3.75 plus or minus 0.2 by 25%, 39% and 52% at 25, 50 and 100 mg/kg. Peripheral neutrophils were reduced at all doses a…
Extraction: extract · Supplied extraction confidence: 0.92. Machine-extracted fields require source verification.