Effect of photodynamic therapy on local muscle treatment in a rat muscle injury model: a controlled trial.
RatCrushLimb / muscle crushSprague-DawleyMalen = 28 rats total, 14 treated and 14 untreated (abstract states…Intraperitoneal photosensitiser with local transcutaneous near-infrared irradiationLP-iDOPE 7 mg/kg; irradiation at 810 nm, 0.1 W/cm, 30 sPhotosensitiser immediately after injury, irradiation 18 hours after injury
Model: Right gastrocnemius muscle contusion by drop-mass method (115 g mass dropped from 1 m)
Fluorescence at 18 h was significantly lower in the treated group (p = 0.020), while IL-6 (p = 0.002) and TNF-alpha (p = 0.001) were significantly higher, consistent with an activated repair response. Histology showed less bleeding, less degeneration and more granulation in the treated group at 24…
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.