Procedure · PARTIAL MATCH, recorded deliberately: the ChEMBL entity is the parent dye indocyanine green (parent CHEMBL1201304 acid form; sodium salt CHEMBL1646), approved 1959, ATC V04CX01, parenteral, not withdrawn. get_mechanism mec_id 8806 gives mechanism_of_action 'Diagnostic agent' with target_chembl_id and action_type NULL IN CHEMBL ITSELF, so the empty target field is a genuine null, not an omission; ICG is registered as an imaging agent, NOT as a photosensitiser. The liposomal iDOPE derivative itself has no ChEMBL entry. Of 10 raw PDT hits, 2 were kept: NCT07609888 uses ICG as an actual photosensitiser with an 810 nm diode laser, and NCT01253759 is an observational ICG-based PDT series in choroidal melanoma. REJECTED: NCT01974622 and NCT00674323 use ICG ANGIOGRAPHY only to guide verteporfin PDT, i.e. ICG as diagnostic not therapeutic; 6 further hits were verteporfin, aflibercept or non-ICG antimicrobial PDT. Both recorded trials are dental or ocular, neither is a trauma indication, and neither uses a liposomal formulation.
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Periodontitis · Chronic Periodontitis (Disorder)
Enrolment: 30 · Results not recorded
Choroidal Melanoma
Enrolment: 46 · Results not recorded
1 studies reported at therapy level; 1 evidence entries itemised.
Model: Right gastrocnemius muscle contusion by drop-mass method (115 g mass dropped from 1 m)
Fluorescence at 18 h was significantly lower in the treated group (p = 0.020), while IL-6 (p = 0.002) and TNF-alpha (p = 0.001) were significantly higher, consistent with an activated repair response. Histology showed less bleeding, less degeneration and more granulation in the treated group at 24…
Extraction: extract · Subtype source: llm · Supplied extraction confidence: 0.9. Machine-extracted fields require source verification.
