Ascorbic Acid Reduces the Adverse Effects of Delayed Administration of Tissue Plasminogen Activator in a Rat Stroke Model.
RatIschaemia-reperfusionCerebral (MCAO/stroke)Malen = 40 rats in four groups (10 per group)Ascorbic acid 500 mg/kg; recombinant tissue plasminogen act…5 hours after stroke onset
Model: Permanent middle cerebral artery occlusion
Ascorbic acid alone (p < 0.001) or combined with the thrombolytic (p < 0.05) significantly reduced infarct volume compared with control or thrombolytic alone. Blood-brain barrier permeability (p < 0.05), matrix metalloproteinase 9 (p < 0.05 versus control, p < 0.01 versus thrombolytic) and brain oe…
Extraction: extract · Subtype source: rule · Supplied extraction confidence: 0.75. Machine-extracted fields require source verification.