Neuregulin-1 inhibits neuroinflammatory responses in a rat model of organophosphate-nerve agent-induced delayed neuronal injury.
RatChemical/toxinSprague-Dawleymale
Model: Organophosphate nerve agent intoxication with diisopropylfluorophosphate (DFP) causing delayed neuronal injury and neuroinflammation
DFP caused microglial activation across multiple brain regions and increased mRNA of about 1,300 hippocampal genes at 24 h. NRG-1 suppressed microglial activation and reduced by 50% or more a small fraction of DFP-induced genes, predominantly inflammatory. IL-1beta and IL-6 mRNA increases were sign…
Extraction: extract · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.