Hydrogen-rich saline attenuates acute renal injury in sodium taurocholate-induced severe acute pancreatitis by inhibiting ROS and NF-κB pathway.
RatChemical/toxinWistarmaleintravenous (tail vein) with subcutaneous compensation6 mL/kg intravenously plus 20 mL/kg subcutaneouslyafter successful modelling
Model: Severe acute pancreatitis induced by retrograde pancreatic duct infusion of sodium taurocholate, with secondary acute kidney injury
Hydrogen-rich saline lowered serum creatinine and BUN, reduced pancreatic and renal histological injury, lowered renal MDA and MPO, reduced serum IL-1beta and IL-6 and renal TNF-alpha and HMGB1, and reduced tyrosine nitration, IkappaB degradation and NF-kappaB activation, while increasing renal IL-…
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