Substance P promotes wound healing in diabetes by modulating inflammation and macrophage phenotype.
RabbitWoundexogenous delivery to the wound
Model: Diabetic skin excisional wound in mice and rabbits, with additional substance P deficient and neurokinin-1 receptor deficient mouse models
Substance P treatment improved wound healing in diabetic mice and rabbits, while substance P or neurokinin-1 receptor deficiency impaired healing. Substance P bioavailability was reduced in diabetic skin and treatment restored an acute inflammatory response, allowing progression to the proliferativ…
Extraction: extract · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.