Astaxanthin attenuates early acute kidney injury following severe burns in rats by ameliorating oxidative stress and mitochondrial-related apoptosis.
RatBurnUnspecifiedSprague-Dawleymaledose-dependent effect reported, individual doses not stated…
Model: Classic severe burn rat model with early post-burn acute kidney injury
Astaxanthin improved renal tubular injury and reduced serum creatinine and neutrophil gelatinase-associated lipocalin, relieved renal oxidative stress and tubular apoptosis, increased Akt and Bad phosphorylation and down-regulated cytochrome c and caspase-3/9. Effects were dose-dependent and revers…
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