The Benefits of Astaxanthin as Add on Therapy in the Management of Painful Diabetic Neuropathy Patient: Randomized Clinical Trial
Painful Diabetic Neuropathy
Enrolment: 60 · Results not recorded
Nutraceutical · EXACT ENTITY MATCH. CHEMBL1255871, max_phase 3, first_approval NULL (food-grade carotenoid, never a registered drug), natural_product=true, therapeutic_flag=false, not withdrawn. get_mechanism mec_id 9399 gives only a descriptive pharmacological class with target_chembl_id and action_type NULL IN CHEMBL ITSELF, so the empty target field is a genuine null rather than an omission. 5 of 10 raw trial hits were kept as genuinely astaxanthin-containing; REJECTED as term-collision or multi-ingredient false positives: NCT01647984 Ritmonutra, NCT07604870 and NCT06880939 krill oil, NCT01562080 Armolipid Plus, NCT04071977 undefined combined antioxidant therapy. Indications are diabetic neuropathy, male infertility, knee osteoarthritis, bioavailability and PCOS; NONE is a trauma indication. NCT05138549 is TERMINATED at n=16.
0 linked trials carry an injury-indication flag. These flags support record-level exploration and sit alongside the stringent aggregate counts described in Methods.
Painful Diabetic Neuropathy
Enrolment: 60 · Results not recorded
Osteoarthritis, Knee · Joint Inflammation
Enrolment: 16 · Results not recorded
PCO - Polycystic Ovaries · Obesity and Obesity-related Medical Conditions
Enrolment: 44 · Results not recorded
Infertility, Male
Enrolment: 80 · Results not recorded
Bioavailability
Enrolment: 13 · Results not recorded
1 studies reported at therapy level; 1 evidence entries itemised.
Model: Classic severe burn rat model with early post-burn acute kidney injury
Astaxanthin improved renal tubular injury and reduced serum creatinine and neutrophil gelatinase-associated lipocalin, relieved renal oxidative stress and tubular apoptosis, increased Akt and Bad phosphorylation and down-regulated cytochrome c and caspase-3/9. Effects were dose-dependent and revers…
Extraction: extract · Supplied extraction confidence: 0.65. Machine-extracted fields require source verification.