Xenon Treatment Protects against Remote Lung Injury after Kidney Transplantation in Rats.
Model: Rat renal transplantation model in which the Lewis renal graft was stored in 4 degrees C Soltran preserving solution for 24 h before transplantation into a Lewis recipient, causing remote lung injury; parallel in vitro studies used A549 human lung epithelial cells challenged with H2O2, TNF-alpha or conditioned medium from hypothermia-hypoxia insulted HK-2 cells
Recipients of ischaemic renal grafts developed pulmonary injury. Xenon enhanced HIF-1alpha, attenuating HMGB-1 translocation and NF-kappaB activation in A549 cells, and enhanced phospho-mTOR, HIF-1alpha and Bcl-2 with increased lung cell proliferation. After grafting, HMGB-1 translocation and TLR-4…
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