Pirfenidone Attenuates Microglial Reactivity and Reduces Inducible Nitric Oxide Synthase mRNA Expression After Kainic Acid-Mediated Excitotoxicity in Pubescent Rat Hippocampus.
RatChemical/toxinWistarmaleorogastric tube (oral gavage)325 mg/kg, single dose90 min after kainic acid exposure
Model: Kainic acid-induced excitotoxic hippocampal injury with limbic seizures, induced by intraperitoneal injection of 12 mg/kg kainic acid
Pirfenidone dramatically reduced microglial activation seen with isolectin B4 staining and MHC II immunohistochemistry, and down-regulated inducible nitric oxide synthase mRNA measured 6 h after kainic acid injection.
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