Topical treatment with pterostilbene, a natural phytoalexin, effectively protects hairless mice against UVB radiation-induced skin damage and carcinogenesis.

Topical treatment with pterostilbene, a natural phytoalexin, effectively protects hairless mice against UVB radiation-induced skin damage and carcinogenesis.

Model: UVB radiation-induced skin damage and photocarcinogenesis; acute UVB at 360 mJ/cm2 and chronic UVB at 180 mJ/cm2 three doses per week for 6 months; parallel in vitro work in HaCaT immortalised human keratinocytes

Pterostilbene prevented acute UVB-induced increases in skin fold, thickness and redness and photoaging-associated wrinkling and hyperplasia, and prevented chronic UVB-induced skin carcinogenesis, with 90% of pterostilbene-treated mice free of skin carcinomas versus numerous tumours in all controls.…

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